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Search Results for " complement factor b "

Targets Recommended: Complement System

8

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9189	Iptacopan hydrochloride Iptacopan HCl,LNP023 hydrochloride	Complement System	Immunology/Inflammation
	Iptacopan hydrochloride (LNP023 hydrochloride) 是一种可口服、高效和高选择性的因子 B 抑制剂，IC50 为 10 nM。 LNP023 显示与人因子 B 的直接、可逆和高亲和力结合，KD 为 7.9 nM。
T62276	Factor B-IN-3
	Factor B-IN-3 是一种补体因子 B (complement factor B) 的有效抑制剂。Factor B-IN-3 能够用于研究炎症和免疫相关疾病。
T62688	Factor B-IN-4
	Factor B-IN-4 是一种补体因子 B (complement factor B) 的有效抑制剂 (IC50: 1 μM)。Factor B-IN-4 能够用于研究炎症和免疫相关疾病。
T62292	Factor B-IN-2
	Factor B-IN-2 是一种补体因子 B (complement factor B) 的有效抑制剂 (IC50: 1.5 μM)。Factor B-IN-2 能够用于研究炎症和免疫相关疾病。
T62689	Factor B-IN-5
	Factor B-IN-5 是一种补体因子 B (complement factor B) 的有效抑制剂 (IC50: 1.2 μM)。Factor B-IN-4 能够用于研究炎症和免疫相关疾病。
T76814	Lampalizumab
	Lampalizumab (RG 7417) 为靶向补体通路中补体因子 D (Factor D) 的人源单克隆抗体。通过结合外位点，该药物立体阻断因子 B 进入活性位点，用于老年性黄斑变性 (AMD) 研究。
T38803	Factor D inhibitor 6
	Factor D inhibitor 6 is a potent, highly selective, orally active compound that specifically inhibits the activity of factor D (FD). It demonstrates an IC50 of 30 nM and a Kd of 6 nM. Notably, Factor D inhibitor 6 does not exhibit any inhibitory effects against factor B, classical and lectin complement-pathway activation, nor does it interfere with a broad array of receptors, ion channels, kinases, and proteases.
T74683	IONIS-FB-LRx
	IONIS-FB-LRx 是一种靶向补体因子 B (CFB) 的特殊反义寡核苷酸(ASO)。IONIS-FB-LRx 能有效降低 CFB 的循环水平。IONIS-FB-LRx 可用于地理萎缩 (GA) 研究。

化合物

Iptacopan hydrochloride

Cat.No: T9189

Synonym: Iptacopan HCl,LNP023 hydrochloride

Target: Complement System

Factor B-IN-3

Cat.No: T62276

Factor B-IN-4

Cat.No: T62688

Factor B-IN-2

Cat.No: T62292

Factor B-IN-5

Cat.No: T62689

Cat.No: T76814

Factor D inhibitor 6

Cat.No: T38803

Cat.No: T74683

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04921	Complement factor B/CFB Protein, Human, Recombinant (His) ARMD14,GBG,AHUS4,PBF2,complement ...	Human	HEK293 Cells
	Complement factor B/CFB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.5 kDa and the accession number is AAH04143.1.
TMPH-02607	Complement factor B Protein, Mouse, Recombinant (His) C3/C5 convertase,Complement factor B	Mouse	E. coli
	Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase.
TMPJ-00472	Vitronectin Protein, Human, Recombinant (Truncated, His) Vitronectin,Complement S-protein,Serum Spreading	Human	HEK293 Cells
	Vitronectin, also known as VTN, is a large glycoprotein found in blood and the extracellular matrix (ECM). Vitronectin is a plasma glycoprotein implicated as a regulator of diverse physiological process, including blood coagulation, fibrinolysis, pericellular proteolysis, complement dependent immune responses, and cell attachment and spreading. Blocking of Hic(a member of the pneumococcal surface protein C (PspC) family) by specific antiserum or genetic deletion significantly reduced pneumococca...
TMPH-03038	Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO) Cobra venom factor,Complement C3 ...	Naja kaouthia	E. coli
	Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely re...
TMPH-03271	Complement factor D Protein, Rat, Recombinant (His & Myc) Adn,C3 convertase activator,Properdin factor D,...	Rat	HEK293 Cells
	Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 29.8 kDa and the accession number is P32038.
TMPK-01413	H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi) H-2K,OVA,MHC,H2-K1	Mouse	HEK293 Cells
	Ovalbumin (OVA) has been historically a popular source of such antigens, since OVA can induce both humoral and cellular immune responses based on well-characterised peptide epitopes. The OVA257-264 octapeptide was one of the frst OVA epitopes to be characterised, it has an amino acid sequence SIINFEKL, which is recognised by cytotoxic T lymphocytes. SIINFEKL forms fbrillar assemblies similar to other peptide hydrogels. Te immunoactive properties of this peptide can therefore be related to its se...
TMPK-01412	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi) SARS-CoV-2 epitope,MHC	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.
TMPK-01416	HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated MHC,SARS-CoV-2 epitope	Human	HEK293 Cells
	HLA-B15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype.

重组蛋白

Complement factor B/CFB Protein, Human, Recombinant (His)

Cat.No: TMPY-04921

Species: Human

Expression System: HEK293 Cells

Complement factor B Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02607

Species: Mouse

Expression System: E. coli

Vitronectin Protein, Human, Recombinant (Truncated, His)

Cat.No: TMPJ-00472

Species: Human

Expression System: HEK293 Cells

Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)

Cat.No: TMPH-03038

Species: Naja kaouthia

Expression System: E. coli

Complement factor D Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03271

Species: Rat

Expression System: HEK293 Cells

H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi)

Cat.No: TMPK-01413

Species: Mouse

Expression System: HEK293 Cells

HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01412

Species: Human

Expression System: HEK293 Cells

HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01416

Species: Human

Expression System: HEK293 Cells

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